ECOG Protocols Active as of 08/20/08

Click on the protocol number to view the NCI's PDQ description of the protocol.


BREAST COMMITTEE


ProtocolTitle
40101 Cyclophosphamide and Doxorubicin (CA)(4 vs 6 Cycles) Versus Paclitaxel (4 vs 6 cycles) as Adjuvant Therapy for Breast Cancer in Women with 0-3 Positive Axillary Lymph Nodes: A 2X2 Factorial Phase III Randomized Study
Activation Date: 15-may-2002
E1104 A Phase I/II Study of Suberoylanilide Hydroxamic Acid (SAHA) in Combination with Trastuzumab (Herceptin) in Patients with Advanced Metastatic and/or Local Chest Wall Recurrent Her-2 Amplified Breast Cancer
Activation Date: 23-aug-2006 Suspended: 04-oct-2007
ECOG Participants(requires Adobe Acrobat)
E1105 A Randomized Phase III Double-Blind Placebo-Controlled Trial of First-line Chemotherapy and Trastuzumab with or without Bevacizumab for Patients with HER-2/NEU Over-expressing Metastatic Breast Cancer
Activation Date: 09-nov-2007
E5103 A Double-Blind Phase III Trial of Doxorubicin and Cyclophosphamide followed by Paclitaxel with Bevacizumab or Placebo in Patients with Lymph Node Positive and High Risk Lymph Node Negative Breast Cancer
Activation Date: 02-nov-2007
IBCSG2402 A Phase III Trial Evaluating the Role of Ovarian Function Suppression and the Role of Exemestane as Adjuvant Therapies for Premenopausal Women with Endocrine Responsive Breast Cancer (SOFT)
Activation Date: 04-aug-2003
IBCSG2502 A Phase III Trial Evaluating the Role of Exemestane Plus GnRH Analogue as Adjuvant Therapy for Premenopausal Women with Endocrine Responsive Breast Cancer (TEXT)
Activation Date: 04-aug-2003 Suspended: 30-nov-2007
N063D ALTTO: Adjuvant Lapatinib and/or Trastuzumab Treatment Optimisation Study: A Randomised, Multi-centre, Open-label, Phase III Study of Adjuvant Lapatinib, Trastuzumab, Their Sequence and Their Combination in Patients with HER2/ErbB2 Positive Primary Breast Cancer
Activation Date: 15-feb-2008
PACT1 Program for the Assessment of Clinical Cancer Tests (PACCT-1): Trial Assigning IndividuaLized Options for Treatment: The TAILORx Trial
Activation Date: 07-apr-2006
S0221 A Phase III Trial of Continuous Schedule AC + G Vs Q 2 Week Schedule AC, Followed by Paclitaxel Given Either Every 2 Weeks or Weekly for 12 Weeks as Post-Operative Adjuvant Therapy in Node-Positive or High-Risk Node Negative Breast Cancer
Activation Date: 14-nov-2003
S0230 Phase II Trial of LHRH Analog Administration During Chemotherapy to Reduce Ovarian Failure Following Chemotherapy in Early Stage, Hormone-Receptor Negative Breast Cancer
Activation Date: 06-jan-2005
S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer
Activation Date: 15-nov-2005
S0500 A Randomized Phase III Trial to Test the Strategy of Changing Therapy versus Maintaining Therapy for Metastatic Breast Cancer Patients who Have Elevated Circulating Tumor Cell Levels at First Follow Up Assessment
Activation Date: 01-oct-2006

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Revised: 08/20/08