ECOG: The Eastern Cooperative Oncology Group

General Information

  ECOG-ACRIN web site

Clinical Trials
  Guide For Cancer Patients
  What is a clinical trial?
  Why participate?
  Does insurance cover costs?
  What if I change my mind?
  How can I join a clinical trial?
  Active protocols
 Educational Materials
  Selenium E5597
  GI Studies E4203,E5204
  GI E1208
  Head & Neck Cancer E1305
  Leukemia E1910
  Leukemia E1912
  Lung Cancer E1505
  Lung Cancer E5508
  Lymphoma E2410
  Melanoma E1609
  Melanoma E2603
  Prostate CHAARTED E3805
  Cancer in Siblings E1Y97
  Non-Hodgkins Lymphoma E4402
  Breast E2108
  Breast Cancer PACCT1: TAILORx
  Informational Videos
  Trial Summary Results

Pathology and
Laboratory Science

  Pathology and Lab Science

Trial Monitoring
  Data Safety Monitoring Committee

Member Institutions
  Institutions by state
  Alphabetical listing

Become a Member
  Joining ECOG-ACRIN

  Publications bibliography
  Job Openings
  Future Group Meeting Dates

Scales and Criteria
  ECOG Performance Status
  Common Toxicity Criteria

Cancer Information
  Colon Cancer Video
  Cancer Survivor Publications
  Releasing Results Guidelines

Other Cancer Sites
  Main Institutions' Sites
  Other Cooperative Groups
  Advocates/Support Groups



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ACCRUAL: The number of patients entered in a study.

ACROMEGALY: A chronic disease of adults caused by oversecretion of the pituitary growth hormone and characterized by enlargement of parts of the skeleton, especially the nose, ears, jaws, fingers, and toes.

ANEMIA: A lower than normal number of red blood cells in the blood.

ARM: A specific therapy program under study, often used interchangeably with treatment program, treatment regimen, treatment arm, or treatment. Used when referring to a particular treatment regimen in a study that has more than one regimen.

BENIGN (TUMOR): A tumor that is not cancerous. Benign tumors are rarely a threat to life and can usually be surgically removed.

CARCINOID TUMOR: A tumor occurring in the small intestine, appendix, stomach, or colon.

CHEMOTHERAPY: The treatment of disease, such as cancer, by drugs.

CHOLESTEROL: A fat-like steroid found in animal fats and oils and also produced by the body.

CLINICAL TRIAL: A research study designed to answer specific questions about a particular disease.

COLORECTAL CANCER: Cancer of the colon (large intestine, bowel).

DIAGNOSIS: The process of identifying a disease by its characteristic signs, symptoms, and laboratory findings. Plural: diagnoses.

DOSAGE: The determination and regulation of the size, frequency, and amount of an agent or medication.

ELIGIBILITY: Criteria that must be met prior to patient entry onto a study.

ESTROGEN: One of the female sex hormones produced mainly by the ovaries. Males also produce estrogen, but in much smaller quantities. Estrogen is responsible for the development of the female secondary sex characteristics and also has a major role in the menstrual cycle.

HEPATITIS: Inflammation or swelling of the liver.

INTERFERON ALPHA: A drug (cytokine class) used in cancer therapy.

INTERGROUP: A collaboration of cooperative groups in order to conduct clinical trials.

MALIGNANT: Cancerous - abnormal uncontrolled growth of tissue.

MALIGNANCY: A mass of cancer cells that may invade surrounding tissues or spread to different areas of the body (see metastases).

MELANOMA: An aggressive type of skin cancer.

METASTASES: The spread of cancer cells to distant areas of the body by way of the lymph system or blood stream.

MULTIPLE MYELOMA: A cancer of the bone marrow in which there is uncontrolled growth of plasma cells.

ONCOLOGY: The science dealing with the properties and features of cancer, including the causes and the disease process.

PERFORMANCE STATUS: The physical status of a patient (Karnofsky scale, ECOG scale), which represents the level of activity.

PLACEBO: A substance that has no effect on a patient. It is sometimes given to members of the control group during an experimental trial.

PROTOCOLS: A formal document for a study, written by a scientist, that details the exact patient population, the treatment selection rational, hypotheses under study, method of treatment, method of observation, and data to be reported.

RADIATION THERAPY/RADIOTHERAPY: Treatment of cancer with high-energy radiation.

RANDOMIZATION: A statistical plan by which treatments are assigned by chance to patients under study. Randomization is the basis of the statistical design used in the clinical trial setting.

SQUAMOUS CELL CARCINOMA: A type of skin cancer that usually appears as red, scaly patches on the lips, face, and tips of ears, but can also occur in other sites, such as the cervix and lungs.

STAGE OF DISEASE: An evaluation of the extent of the disease. Classifying disease based on stage at diagnosis helps to determine appropriate treatment and prognosis.

TAMOXIFEN: An anti-estrogen used in cancer therapy.

TRIGLYCERIDES: Fats - found in the bloodstream and stored in adipose (fat) tissue.

TUMOR: A new and spontaneous growth of tissue that forms an abnormal mass. Tumors can be benign or malignant.

TUMOR GRADE: A classification of tumor size.

How to contact ECOG

All contents copyright © 1998-2000 Eastern Cooperative Oncology Group.
All rights reserved.
Revised: October 3, 2000