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ECOG Introduction to ECOG Clinical Trials Guide For Cancer Patients What is a clinical trial? Why participate? Does insurance cover costs? What if I change my mind? How can I join a clinical trial? ECOG's active protocols Patient Information Selenium E5597 GI Studies E4203,E5202,E5204 Melanoma E2603 Prostate CHAARTED E3805 Cancer in Siblings E1Y97 Non-Hodgkins Lymphoma E4402 Breast Cancer PACCT1: TAILORx Informational Videos Trial Summary Results Trial Monitoring ECOG Data Monitoring Committee ECOG Institutions Institutions by state Alphabetical listing Joining ECOG Joining ECOG Publications Publications bibliography Announcements TAILORx Webinar Information NCI Press Release: Bevacizumab... Job Openings Future ECOG Meeting Dates Researcher Advocate Partners Young Investigator Symposium NCI-VA Initiative Scales and Criteria ECOG Performance Status Common Toxicity Criteria Cancer Information Breast Cancer Video Colon Cancer Video Cancer Survivor Publications Releasing Results Guidelines Other Cancer Sites ECOG Main Institutions' Sites Other Cooperative Groups Advocates/Support Groups 
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Cancer in SiblingsA study of gene characteristics and cancer in familiesFor patients and full blood siblings with a prior diagnosis of cancer of the breast, colon, lung, or prostate
Genes- the biological factors that determine what we inherit from our parents- are very similar in siblings (children of the same parents). Having certain genetic characteristics may make a person more likely to have cancer. Doctors want to discover if having a particular genetic characteristic will allow us to predict how likely it is that a person and his or her sibling will have a certain type of cancer. To determine this, scientists are examining a large number of genetic characteristics in patients and their siblings who have been diagnosed with cancer of the breast, colon, lung, or prostate. The information from this investigation will be used to benefit future cancer patients and may someday help to prevent cancer from occurring. Hundreds of sibling pairs will take part in this nationwide research study, which is administered by the Eastern Cooperative Oncology Group and supported by the National Cancer Institute.
Questions and answers about this studyWhat is the goal of the study?This study will determine whether certain gene characteristics are the same in siblings who have both been diagnosed with cancer of the breast, colon, lung, or prostate.How will this be determined?Scientists will compare blood samples from each patient and her or his sibling to determine if the genetic characteristics are the same in the same kind of cancer. Written information about the participants' family history of cancer will also be studied.Who is eligible?Patients and their siblings (either a brother or a sister) who have both been diagnosed with the same type of cancer (of the breast, lung, prostate, or colon) may be eligible to participate in the study.If I participate, what will I have to do?You and your sibling will be required to have a sample of blood drawn. You will also be asked to provide information about other family members and cancer.Must I take any drugs, or change my diet or other health habits?No drugs or changes in health habits are required.How do I participate?If you are a patient of an oncology (cancer) doctor who is participating in this study, please ask your doctor for more information. If you are the sibling of a patient who has agreed to participate in this study, someone from the Eastern Cooperative Oncology Group will contact you.You may be eligible to participate in this study if you and a brother or sister have been diagnosed with:
Should you choose to participate in this study, prior to enrollment, please obtain:
Participating institutions include:
Contact InformationFor additional information about this study or to participate, please contact:
Mary Booth through email at mbooth@coh.org
Protocol E1Y97 "Mapping Interactive Cancer Susceptibility Loci"
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